Lovitz was one of the most popular cast members of Saturday Night Live from 1985 to 1990. His most notable SNL characters were Tommy Flanagan, the Pathological Liar, and the Master Thespian. In the animated series The Critic, he played the title character of Jay Sherman.
Lovitz has starred in a number of films from the comedy Rat Race to the musical The Producers. On Broadway, he played the lead role in The Dinner Party. He has sung the national anthem at Dodger stadium and at the U.S. Open.